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2017-04 03 Important News

[Academics][Researcher of the Month] Detecting Ultra-Sensitive Benzene

Professor Kim Hyoun-woo of the Division of Materials Science and Engineering is April’s Researcher of the Month, for his active role in exploring the field of materials science and engineering. In his paper “Ultra-sensitive benzene detection by a novel approach: Core-shell nanowires combined with the Pd-functionalization”, Kim explains how the detection of benzene gas has become much more efficient than ever. The palladium being extra sensitive to benzene gas has been the key to the detection technique which has drawn attention in this field. Kim has discovered the link between palladium and benzene gas. The Pd-functionalized SnO2-ZnO C-S NW is the substance developed by Kim in order to detect benzene, a toxic gas. Since nano-sized palladium particles are added on a cell with SnO2 and ZnO covered on top, the sensor produces a spillover effect, distributing the benzene gas particles along the conduction band. The effectiveness of Kim's model is proven through the gas response. (Photo courtesy of Kim) This is important since benzene gas can be found in everyday life. It is inside cigarette smoke, smog, exhaust fumes and may be found in new houses, creating sick house syndrome. Through Kim’s finding, this benzene gas, which could be lethal to human lives, can be spotted in a much more sensitive manner. Since the sensors and cells created in a smaller size would lead to higher sensitivity, the particles have been selected in nano-sizes. The only problem that could arise with this sensor is that it depends heavily upon the selectivity of which gas it wants to detect. The compatibility between different particles could create great results as Kim has found out in the case of palladium and benzene, while in other cases, disastrous results may be spawned. Kim explains how his model works. Kim wishes to develop better usage of sensors than those that are being distributed in every day life as of now. “I want to find the best usage of a new sensing principle totally different from the current ones,” said Kim. Kim Seung-jun nzdave94@hanyang.ac.kr Photos by Choi Min-ju

2017-03 28

[Academics]Impact of Nickel on Frog Embryos

Environmental pollution permeates many lives of animals and humans and lowers the quality of life due to causes that consist of not only diseases but surprisingly of malformations as well. Professor Gye Myung-chan of the Department of Life Science specializes in the embryology of mammals and amphibians, and the harmful effects of environmental pollutants, such as heavy metals and endocrine-disrupting chemicals (EDC). Graduated from both HYU and its graduate school, he was given many awards and president of various academic societies, such as Korean Society of Environmental Biology. His recently published paper called “Nickel affects gill and muscle development in oriental fire-bellied toad (Bombina orientalis) embryo” observes nickel’s adverse influence to frog’s embryos. Gye is interested in embryology, which is a field of study that observes the early stages of life including the formation of sperm, ovum, and embryo. Even though amphibians include most endangered animals compared to other species, there is not enough research about frogs. This situation applies to studies about how organisms are affected by environmental pollutants occurred by artificial causes, such as nickel and other heavy metals, which is being researched by a lot of scholars. Searching for his own domain of studies, Gye decided to conduct an experiment regarding how nickel can negatively affect Bombina orientalis, a common widespread frog that lives in Korea. Due to its mild disposition, big and thus easily observable eggs, and the small body size being the advantage of handling with ease, the frog was chosen for the subject of Gye’s studies. “I also wanted to show that Korean frogs can be used as an important biological resource.” Gye included. To begin with, Gye let the frog’s embryos grow in multiple amount of nickel for 168 hours and found out the sublethal and lethal concentrations of the substance. “Sublethal concentration, which is about 1~10 uM (the 1,000,000/1 of 1 mole) is where embryos survive to display various abnormalities, such as underdevelopment of gills, tail dysplasia, bent trunk, and abdominal blister. On the other hand, lethal concentration, approximately 100 uM, is where death of embryos disenable the observation of their malformation,” said Gye. Various deformations of tadpoles under sublethal nickel concentration. (Photo courtesy of Gye) The period where the embryos were most sensitive to nickel was the ‘pre-muscular response to muscular response stages’. These stages are when the embryos develop to use their muscles to make their tail move. “Like the thalidomide incident where the babies of women who take doses of the medicine to reduce nausea in the early stage of their pregnancy became deformed, there is a much more sensitive period of certain substance’s adverse effects, ” explained Gye. The deformation of the embryo's tail during ‘pre-muscular response to muscular response stages’. The stage is where the tadpole starts to move its tail using its muscles. (Photo courtesy of Gye) Seeing that the tadpoles displayed signs of deformations, especially the abnormality of tail muscles, he cloned their DNA that controls the development of the muscles to find out the exact causes for the malformations. “DNA transcripts RNA, and it makes proteins. Proteins that are needed for composing muscles is then selectively turned on by hormones. Next, the signals of the hormones are caught by the transcription factors that help produce RNA,” Gye described. Then, he discovered that nickel prevented the activation of the transcription factors such as myogenic regulatory factor 4 mRNA, thus inhibiting the development of muscle proteins. Gye also found out that exogenous calcium reacts oppositely to nickel’s adverse effects. “The composition of calcium is similar to that of nickel. They compete against each other and then calcium replaces nickel, “ Gye mentioned. Gye found out that calcium’s substitution of nickel restores some of its negative effects to the embryos by re-increasing protein levels and calcium-dependent kinase activities, which has the role of changing the structures of proteins. “The dangers of nickel and other heavy metals apply not only to frog embryos, but also to other species and humans. The only solution to the problem is to reduce and prevent the spills of nickel caused by mining and industrial production, and law enforcement that regulates the spills is necessary,” Gye explained. Greatly interested in environment and the humans that live in it, Gye is currently leading the Enterprise Organization for Development of Alternative Chemicals of EDC of the Ministry of Science, ITC, and Future Planning. “I hope, through my research that I could realize Hanyang’s founding philosophy, Love in Deed, by enabling people to live healthier. I wish I could benefit the society by conducting useful and practical research,” Gye said. "I want to realize the founding philosophy of Hanyang by heightening the quality of life through my research." Jang Soo-hyun luxkari@hanyang.ac.kr Photos by Choi Min-ju

2017-03 25

[General]Cycling Around Seoul

Cycling is a form of great exercise, and a mode of green transportation that takes people along far greater distances compared with walking. With certain problems affiliated with owning a bicycle, whether it be the cost or the fear of getting the bike stolen, there is no longer any need to worry- with Seoul Bikes being provided around the city. Currently, 450 stations with 5,600 bikes are available all around Seoul and is estimated to increase in number, up to 20,000 bikes, with 1,300 stations to be built by the end of this year. Seoul Bike Two types of tickets are available for Seoul Bikes: seasonal vouchers, and one-day membership vouchers. The price of a one-day voucher is 1,000 won, but in order to ride the bike for the whole day, it has to be returned to any station within one hour since its rental time and additional charges would be applied if the bicycle is not returned within the original rental time. In other words, the bike rental service itself is available for the whole day under the premise that bicycles are returned to any station in Seoul every hour. Procedures for renting Seoul Bikes. (Photo courtesy of Seoul Bike) Most stations exist where a lot of people visit or pass through, which makes it easier to access the bikes. Since mobile applications are also available, there is no need to worry whether a certain station has all of its bikes rented out or not. The app's services come with the locations of bike stations and how many bikes are available in real-time. Additionally, useful features such as the distance travelled, riding hours, calorie consumption, and CO2 reduction make the bicycle ride more worthwhile. Riding along the bike roads will lead to Han River. Courses around Hanyang University Some of the best bike courses are provided around Hanyang University following the Jung-rang stream. The courses lead to Seoul Forest, Cheong-gye stream and as far as Han river as well. In addition, since there are quite a lot of Seoul Bike stations on the way, which makes the check-in and out processes much easier. Road signs are available, and places to rest on the way are also offered. Great views on the way to Seoul Forest. As the weather gets warmer, it would be quite nice to travel around Seoul on a bike. It's great exercise as well as it being an opportunity to contribute to CO2 reduction compared to riding cars or buses. Kim Seung-jun nzdave94@hanyang.ac.kr Photos by Kim Seung-jun

2017-03 22

[Event]Foreign students from Hanyang University participate farm experience (1)

Foreign students at Hanyang University participated in a farm experience event in Muwol Village, Damyang-gun, South Jeolla Province on June 19. Hanyang University Office of International Affairs organized a field trip event to provide foreign students with opportunities to experience rural culture in Korea and help revitalize rural areas. About 40 foreign students attending the event were mainly from the US, Germany, France, Kazakhstan, and China. In addition to making the rice glue balls, they also enjoyed making rice cakes and experiencing natural dyeing. ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience ▲ Foreign students at Hanayang participating in farm experience

2017-03 21 Important News

[Academics]Genetic Architecture of Rheumatoid Arthritis

Rheumatology is a rather unexplored branch in the medical field, and its causes and cures have not yet been fully prepared. However, Professor Bae Sang-cheol of the College of Medicine at Hanyang University stands as one of the pioneers to define and research the causal factors of rheumatology and discover better remedies. In his research “Update on the genetic architecture of rheumatoid arthritis”, Bae clearly defines the factors of rheumatoid arthritis with regards to human genetics, and predicts the possibility for precision medicine. Bae is one of the pioneers in Korea to research and advance cures rheumatoid arthritis. In his paper, Bae has organized the causes and possible remedies for rheumatology researched in the last five years- collecting all data with advanced medical technology. Rheumatism hasn't been explored completely yet, so its causes are only speculated to be genetic and environmental factors. “Rheumatism is an autoimmune disorder, which means that the causes tend not to be external factors. It's assumed that 60% of the causes is the immune system attacking upon itself, acting out of misconception,” said Bae. Human genetic studies into rheumatoid arthritis have uncovered more than 100 genetic loci associated with susceptibility to the disease. This means that the majority of factors are highly shared across multiple ancestral populations. Bae and his fellow researchers organized the data on impaired immune processes and disease phenotypes for rheumatism. “The ultimate goal of this research paper was to enhance the possibility of finding the repurposed drug for each rheumatoid arthritis patient,” mentioned Bae. Since 2005, medical technology developed rapidly, especially in the genome field. For about a decade, a significant amount of the data was collected on genome structures that are likely to influence the rheumatoid diseases. “The grand development in this area is that now, technology can examine the whole genetic variants, instead of individual ones, using the whole genome analysis technique,” said Bae. Rheumatology-related genetics directly affect gene expression and protein function, and also influence cell signaling pathways. According to the cumulated data, this process causes the immune function to be disordered, and spawns diseases in patients. “Proteins that are encoded by rheumatoid risk variants have the potential to help the development of targeting drugs,” Bae explained. Two years were spent in total on the production of this paper, and each process was intricate. First, Bae was invited to co-write with rheumatology experts to analyze the causes and possibilities of advancing repositioning drugs. Then, he had to edit and peer review the analysis and consult with graphic designers to obtain desired pictures of rheumatoid figures. “All these processes took a long time, but interacting with peer reviewers was particularly helpful in advancing this article,” said Bae. Bae stresses the importance of enhancing research on drug repositioning. Drug repurposing, also called as drug repositioning, is applying and utilizing existing medicine to develop into rheumatoid remedies. This technique significantly curtails the cost and time to invent new drugs that target rheumatoid diseases, because existing drugs have already been approved for its pharmacodynamics. Also, the development of precision medicine, which therapeutically targets for personalized rheumatoid state, is being accelerated. “Rheumatoid arthritis does not signal the body in a unique way- it feels more like a cold in the beginning. But alerting oneself to get regular health checks may help to prevent the threatening disease." Bae's ultimate goal is to develop and contribute to organic and personalized rheumatoid arthritis drug invention. His efforts to contribute to the field of rheumatology are prominent, just like his favorite poem, 'The Road Not Taken', by Robert Frost. “Reminding yourself of the original attitude and always trying your best will undoubtedly lead you to success,” advised Bae. Kim Ju-hyun kimster9421@hanyang.ac.kr Photos by Choi Min-ju

2017-03 20

[Performance]Hanyang University ranked 34th in THE 'Industry Collaboration'

Hanyang University ranked 34th in the world rankings of universities that publish the highest proportions of research output in collaboration with industry as announced by the Times Higher Education (THE). The UK's Times Higher Education announced the rankings of universities that publish the highest proportions of research output in collaboration with industry from the recent article entitled "South Korean universities lead way on industry collaboration." According to the article, Hanyang University has published 4.06 percent of its total 22,424 publications via collaboration with industry. <The rakings of unversities that show the highest proportions of research output in collaboration with industry (Korean universities)> Ranking (World rankings) University The proportions of collaboration with industry (the number of total publications) 1(1) POSTECH 22.98(13,545) 2(8) Sungkyunkwan University (SSKU) 8.84(30,406) 3(11) KAIST 6.05(20,768) 4(32) GIST 4.11(5,833) 5(34) Hanyang University 4.06(22,424) 6(37) Seoul National University 4(61,449) Among Korean universities, POSTECH was selected as the top university to publish the highest proportions of their research output in collaboration with industry with 22.9 percent of its total 13,545 publications via such links. It was followed by SKKU with 8.84 percent of its total 406 publications, KAIST with 6.058 percent of 20,768, GIST with 4.11 percent of 5,833, Hanyang University with 4.06 percent of 22,424, and Seoul National University with 4 percent of 61,449. UK's Times Higher Education is an university evaluation agency which announces THE world university rankings every year. Unlike world university rankings, Asian University rankings, small universitiy rankings, and emerging university rankings, which are announced by the agency every year, the rankings of universities in collaboration with industry were announced this year for the first time based on data from 2007 to 2016.

2017-03 17

[Event]Hanyang University Institute of Euro African Studies Hosts Investment Seminar

Hanyang University Institute of Euro African Studies will host an investment seminar with African experts at Seoul Campus College of Social Sciences Building on the 21st. This seminar, hosted by the National Research Foundation of Korea, and sponsored by IBK, is an exploration of the economic and political situation and investment methods of Algeria and other African nations. Mohammed EI Amine Derragui, the Algerian ambassador to Korea, and Mustafa Khiati, a professor at the University of Algiers, will explain the current status of Algeria. Subsequently, Shin Hyeong-seob, a Hanyang University professor, and Choi Dong-ju, a professor at Sookmyung Women's University, will present the current status quo of other African countries. Kim Sung-soo, a professor in the Department of Political Science and International Studies said, "Korea needs to focus on emerging markets in Africa to diversify its export markets." He also pointed out that acquiring accurate knowledge of the current situation in Africa is of primary importance.

2017-03 14 Important News

[Academics]Way to Improve Korean Healthcare Ecosystem by U-healthcare System

Professor Lee Chang-won of School of Business is an expert in the field of healthcare management. From his years at graduate school in the United States, Lee became interested in telemedicine, so-called ubiquitous healthcare (u-healthcare) that can provide healthcare service and treatments to its patients regardless of time and location. After coming back to Korea, Lee started to study more deeply about healthcare management and also wrote a paper on how to effectively and efficiently allocate hospital resources. One of his most recent paper, “Improving healthcare quality: A technological and managerial innovation perspective,” specifically researched on quality characteristics of u-healthcare services for a health care service that influences users’ (hospital staffs) usage intentions. Prof.Lee is an expert in the field of healthcare management. The background of u-healthcare system starts with the aging society, a society with more than 7 percent of people who are older than 65 in a whole population. Such social changes have become a serious problem in many countries. In Korea as well, due to the increasing life expectancies and lowering birth rate, there are increasing number of elderlies. Societal aging influence on nearly every factor that affect an individual’s life quality, from economic growth, labor markets, housing, and health. To be more specific, it leads to reduction of productive workforce, while the costs of healthcare for the elderly greatly increases. Thus, it became crucial for the Korean government’s policy makers to initiate an innovative IT-based healthcare system to help people get access to qualified, but more affordable healthcare services. “In the case of patients who need regular medicine subscription or examination, it is unnecessary for them to visit hospitals every time. I think the u-healthcare system will be useful for both patients who requires long-term care and who lives far away from hospitals,” said Professor Lee. “There are various identified quality characteristics of u-health care. It includes, connectivity, compatibility, complexity, perceived benefit, and perceived trust. It was our purpose of the study to research on how such characteristics actually influence on the usage attention of hospital staffs,” explained Professor Lee. Thus, it is crucial for Korea’s policy makers to understand usage intentions of its stakeholders to later plan and implement the system better. To do so, Prof. Lee and his team did an empirical research on the 142 staff (physicians, nurses, technicians, and administrative staff) of hospitals in Korea. They used multiple survey methods via both online and offline to collect the needed data. The survey included about 3-4 pages of questions to understand their wiliness for new u-healthcare. The graph shows the overall framework of the research done in the paper. (Photo courtesy of Prof. Lee) The result showed several interesting connection or relevance between the characteristics of u-healthcare and usage intention of hospital staffs. First, it showed positive relationships with connectivity, compatibility and performance expectancy. It explained how an individual expects themselves to perform better with u-healthcare system when one has an ability to connect with u-healthcare system anytime anywhere. On the other hand, complexity and performance expectancy showed negative responses from the staffs. If a system is complex and difficult, taking more time to handle easily, it showed that their expectancy of performance is likely to reduce. “There were also quite high conservative responses from some of the staffs from the concern that u-healthcare is more accessible and affordable to patients,” said Prof Lee. “However, this study identifies benefits of u-healthcare system. Thus, it is a new task for us to suggest a new solution for people who are reluctant to adopt and use new technologies,” added Prof. Lee. Last but not least, Prof. Lee shared some more thoughts about the future of healthcare industry or management. “I feel that there are still misconceptions about “managing” healthcare and hospitals, people easily think that those two concepts of hospital and management cannot go along since management is all about seeking a private interest of a business organization. I think we definitely need a change of recognition,” said Prof. Lee. According to him, healthcare business or management should be more comprehensively compromised on consensus made among key players of healthcare ecosystem. “Managing an organization is not about promoting an interest of a certain group of people, but it is about considering the purpose (or mission) of every individual organization resulting in making a better society,” concluded Prof. Lee. Prof. Lee will continuously strive to develop better hospital ecosystem in Korea. Yun Ji-hyun uni27@hanyang.ac.kr Photos by Kim Yoon-soo

2017-03 10

[Performance]2017 QS World University Rankings By Subject

The QS announced the 2017 World University Rankings By Subject in 46 different subject areas on March 8th on www.topuniversities.com. Hanyang University ranked within the top 200 in 20 different subjects areas including 5 more subjects than last year. Hanyang University has shown a large improvement this year. 12 out of 20 subject areas within the top 200 climbed its rank. Civil and Structural Engineering, in particular, has ranked within the top 50 (43rd) for the first time. Social Policy and Administration, previously outside the 200 ranking, has climbed 3 ranks to the 51~100 range, and Linguistics moved up 2 ranks to the 51~100 range showing a strong upward trend. In addition, Computer Science, Electrical & Electronic Engineering, Chemistry, Environmental Science, Physics and Astronomy, Business and Management, Communication & Media Studies, Politics & International Studies, and Sociology moved up a rank. . Hanyang’s ranking are as follows: Civil and Structural Engineering (total 1 subject) ranked within 1~50 range; Architecture, Linguistic, Chemical Engineering, Electrical & Electronic Engineering, Mechanical·Aeronautical & Manufacturing Engineering, Chemistry, Materials Science, Social Policy & Administration, and Sports-Related Subjects (total 9 subjects) ranked within top 51~100; Computer Science, Pharmacy & Pharmacology, Environmental Science, Business and Management, and Politics & International Studies (total 5 subjects) ranked within the top 101~150; Physics & Astronomy, Accounting & Finance, Communication & Media Studies, Law, and Sociology (total 5 subjects) ranked within the top 151~200. Four new subjects were included in the QS World University Rankings By Subject to the 42 existing ones making 46 subjects in total. The subject rankings were classified into four categories: ① academic evaluation ② alumni reputation ③ paper quotation ④ H index. The evaluation method was the same as last year. 1-50 are ranked individually, but rankings after 50 are grouped by a 50 ranking range. The Chosun Ilbo reported that 14 departments in Korean universities were ranked in the top 20, twice as high as last year, but not in the top 10, meaning that they did not succeed in entering the top level. The article stated: “Korean universities stand out when it comes to engineering...Hanyang University has entered the top 50 ranks for Civil and Structural Engineering (43rd)”. ▶The QS World University Rankings homepage- Rankings by subjects: www.topuniversities.com/subject-rankings/2017

2017-03 06

[Student]Experiences at Hanyang, Francesca's story

Francesca Barbieri, the student from Humanitas University, the private university at Italy dedicated to the medical sciences, participated Hanyang summer program for her medical training. She shared her remarkable experiences and memories here at Hanyang University. Prescription For Growing: Learn Skills But Especially Make Friends I would have never imagined to realize such a big project in such a short time. I found myself on the other side of the world just after a few months I started thinking about it. As I knew about the possibility of obtaining a travel grant, I applied and was then accepted by the cardiology Professor Kyung -Soo KIM. Humanitas therefore gave me the opportunity to spend more than 40 days at the Hanyang University Medical Centre, in Seoul. There, I attended the cardiology wards, outpatient visits and the cardiology research laboratory. To tell the truth, the difficulties of such an experience can be many and discouraging. But everything becomes so pleasant and worthy when you meet the right group of people. Professor Kim and his group of physicians, residents, laboratory members and students accepted me as if I had always been one of them. My family and friends were definitely far away, but I found myself in an environment in which I never felt alone, I could ask anything I needed and was given all the possible help. Trying to follow them during the working day was though, with no doubt. I used to spend between 12 and 13 hours per day in the hospital, some in the clinic, some in the laboratories. As a second year student, I felt to have a solid theoretical knowledge but it was the first time for me to approach the practical clinical environment or research designs and laboratory protocols. I arrived as a very worried student, concerned about what to expect. I came out after 40 days with a basic knowledge of the main heart diseases, how to use the laboratory equipment, how to follow an experimental research design. This was achieved thanks to the constant, careful and personal tutoring I was provided, I always had at least one physician or one researcher on my side. I came out as part of a group of friends, and this was the most surprising and precious aspect. The attention they paid to the success and profit of my experience was invaluable. As invaluable is what I have learnt. Sometimes it is unbelievable how much we can grow in such a short time. * Original article at Hunimed.edu (link)