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11/10/2017 HYU News > Academics > 이달의연구자

Title

[Excellent R & D] Professor Lee Sang-hoon (Department of Biochemistry and Molecular Biology, College of Medicine)

Treatment of Chronic Disease with Tissue Regeneration Promotion Research

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http://www.hanyang.ac.kr/surl/M0FQ

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Chronic diseases, such as Parkinson's disease, diabetes, dementia, and degenerative arthitis, cannot be cured and should be managed for life. To treat this, stem cells are being studied in medicine. Professor Lee Sang-hoon (Department of Biochemistry and Molecular Biology, College of Medicine) has been conducting research on embryonic stem cell research for treatment of chronic diseases at the Medical Research Center (MRC) of Hanyang University since 2008. He will carry out further research until 2024.


▲ On November 6th, News H visited Prof. Lee Sang-hoon (Department of Biochemistry and Molecular Biology, College of Medicine) and talked about stem cell and tissue regeneration research. (Source: Professor Lee Sang-hoon)

Increased understanding of stem cells


The relationship between chronic diseases and stem cell research is inevitable. First, in order for the disease to be treated, it is necessary to restore the cells that have been damaged by the disease. The reason why chronic diseases are not treated is because the damaged tissue is an organ that can not be recovered by the human body itself. Neurons and brain cells are destroyed, or genetic problems do not occur due to specific hormones, making a cure impossible. But there is a possibility. If the patient's stem cells can be cloned and cultured well, the cells can theoretically be differentiated into desired cells.

Professor Lee has studied the theoretical techniques in detail. In 2008, Hanyang University MRC (Medical Research Council) conducted a research on the basic mechanism of stem cells under the name 'Stem Cell Control Research Center'. In detail, stem cells are cultured, and the number of stem cells is differentiated into tissue cells. Professor Lee conducted a 'stem cell behavior control study' that controlled this behavior. Since the study of stem cells at the time was at the beginning stage, he has been working on the mechanism of how a series of processes take place. Based on the research, he will carry out this research project.

First of all, this research project will continue the basic mechanism research. In addition to the existing understanding, he will improve the understanding of stem cells, the understanding of the differentiation process, and the plan to apply it to other fields such as stem cells.


▲ Professor Lee's team will continue to study for higher stem cell understanding. (Source: Professor Lee Sang-hoon)

Clinical application, industrialization and internationalization

Through this project, his research team will receive a total of 7 billion research grants for seven years, one billion annually. As a new name, Hanyang University MRC 'Tissue Regeneration Promotion Research Center's goal is to develop cell transplantation and gene therapy technologies for Parkinson's disease, mass-production of stem cells with excellent therapeutic effects, and research on the development of affected parts using astrocytes. Parkinson's disease causes the destruction of dopamine-producing substantia nigra, which is intended for clinical application of cell transplantation or gene therapy. Mass production of stem cells can be used for clinical treatment, so mass production and industrialization are also important targets.

Finally, research using stellate cells is also an important goal. When diseases such as dementia or Parkinson's disease are destroyed, not only the destroyed cells but also the surrounding environment becomes bad. Some of the environment is astrocytes. By transplanting stellate cells made by differentiating stem cells, it can improve the surrounding environment of the brain and help regenerate brain tissue.

In this way, internationalization of research results through clinical application and industrialization process is being prepared. In addition to the domestic medical industry, it is also possible to enter the overseas markets in cooperation with Indonesian companies. In addition, research on the basic mechanism will be carried out continuously, so that degenerative diseases, which were chronic diseases in the future, will be gradually transferred to the treatment side.
 
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