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2020-10 12

[Academics]Professor Lee Dong-yoon obtains a patent on cell encapsulation of xenotransplantation jointly developed with Optipharm

Optipharm announced on the 17th that a patent related to the cell encapsulation of xenotransplantation, jointly developed by Lee Dong-yoon, a professor in the department of Bio-Engineering at Hanyang University, and Optipharm, has been obtained. The name of the patent is "Alignite microcapsule for cell membranes and its manufacturing method." This patent is a technology that reduces side effects after the procedure, such as human immunization and hypoxia, by double-capping with substances called alginate and epigallocatechin gallate (EGCG) when implanting pancreatic cells of mini pigs into the human body. Alginate is a polymeric compound available for human bodies approved by the Food and Drug Administration (FDA) and is a representative material used for cell screening. It is responsible for protecting pancreatic cells from human immunity. The pancreas does not affect the cell's original function as it can absorb the oxygen and nutrients needed for cell growth and secrete insulin. However, the fact that it melts in the body over time has been pointed out as a problem. To solve this problem, the patent included a process of coating called EGCG to the alginate that is wrapped in pancreatic cells. This will increase the durability and survival rate of transplanted pancreatic cells and prevent them from easily decomposing in the body. Optipharm's director, Choi Ki-myung, explained, "If you double-coat with EGCG made up of alginate and human-friendly natural substances, many problems such as fibrosis, shorter survival time, and excessive use of immunosuppressive agents can be solved." Optipharm has been focusing on the cross-fertilization business for type 1 diabetes treatment by using the pancreatic cells of transgenic pigs, which are made by inserting or subtracting certain genes. The company plans to conduct a nonclinical experiment on monkeys next year in focus to stabilize the patented technology. Global News Team global@hanyang.ac.kr Translation by: Lee Hee-jin

2020-10 05

[Academics]Hanyang University Industry-University-Research Cooperation Foundation Registered a Patent on Smart Carbon Grid

▲Professor Cho Byeong-wan Hanyang University Industry-University-Research Cooperation Foundation announced on the 14th that the Web2.0 Smart Carbon Grid Platform has been registered as the 2020 patent. The platform allows effective decrease, management, and transaction of Certified Emissions Reduction such as CO2, with the concept of the 4th Industrial Revolution as its basis. Professor Cho Byeong-wan of the Department of Civil and Environmental Engineering, who registered for the patent, mentioned that "on Global New Deal that Jeremy Rifkin, a world renowned economist, wrote that the fossil fuel civilization is predicting the end of the world by 2028." He also explained that "the world is facing a resource crisis, energy crisis, environmental crisis, and climate crisis, calling for a world carbon economy platform that can integrate innovative reduction of carbons and management of technologies. Through the platform, the people will be able to realize the seriousness of the increase in energy consumption and scarcity of the resources. Developed nations, such as the U.S., Japan, and Europe are carrying on priority tasks such as controlling the green gas emission, securing efficiency during the management, and certifying the transaction system to figure out the exact amount and source of carbon emission according to the cities. These measurements are being categorized by cities, regions, areas, institutions, and households to control the total amount efficiently. Professor Cho mentioned, "the patents for the carbon economy platform that intelligently manage and trade carbon emission rights and the greenhouse gas inventory construction, which has the artificial intelligence algorithm used in the Web 2.0 network, can work two-ways (cause-manager-buyer) under the concept of the fourth industrial revolution. They are the most efficient platform technology against global warming so far, such as Youtube and Android of Google, and will surely be used in all countries, cities, institutions, and households around the world." Global News Team global@hanyang.ac.kr Translation by: Lee Won-young

2020-09 24

[Academics]Professor Lee Yoon-jung's joint research team develops a ‘single atom catalyst’ that quadruples fuel cell efficiency

A Hanyang University team led by professor Lee Yoon-jung from the Department of Energy Engineering, in cooperation with KIST Energy Materials Research Group, Dr. Yoon Kyung-joong, and researcher Shin Ji-soo's research team have jointly developed a fuel cell catalyst composed of a single atom. This has shown to decrease the precious metals content compared to the previous catalyst and quadrupled the energy generation efficiency. Unlike the secondary cell, which requires charging, the fuel cell called the ‘tertiary cell’ is a machine that produces energy through the chemical reaction of fuel (hydrogen and oxygen). As it is a method of putting in fuel, it can overcome the disadvantages of having to charge for two hours, which is a relatively long time. Especially, the solid oxide fuel cell is currently actively researched due to its advantage of working in high temperatures above 700 degrees Celsius. Platinum catalyst is required to obtain economic feasibilities of electricity production by increasing the chemical reaction efficiency of fuel cell. Since platinum is a precious metal which is quite expensive, it is an obstacle to fuel cell commercialization. A conceptual diagram of single atom catalyst. The black round marble (right upper side) inside the circle is the cerium oxide, with yellow spots of platinum atoms on its surface. (Photo by: KIST) The method for safe operation and efficiency enhancement when only using a small amount of platinum has been found by the joint research team. They strongly combined the platinum atom and cerium oxide nanoparticle, so that platinum atoms can individually show disperse reaction without agglomerating. Because of this strong combination, all platinum atoms can actively participate in the reaction as the dispersed atom status can be remained for a long time. Accordingly, the reaction speed of electrodes could be enhanced by 10 times while minimizing the platinum dose. Furthermore, it has been confirmed through the efficiency test that safe operation for more than 500 hours is possible even in temperatures above 700 degrees Celsius and that the electricity production efficiency of atom catalyst increases 3~4 times compared to the previous method. It is expected to move forward the commercialization of solid oxide fuel cell as the next generation eco-friendly fuel electricity. The solid oxide fuel cell catalyst allowed catalyst synthesis when the fuel cell operates in a high temperature after the injection of a solution, which has platinum and ceric ions, into the fuel cell. Moreover, it is expected to be applicable to previous fuel cell as it can be injected easily into the electrode without special equipment. The research team said, “Commercialization of solid oxide fuel cell will be advanced by enhancing its efficiency” and that “we need technology developments that can synthesize large amounts of atom catalyst through succeeding protocols.” This research was made possible with the support of the Ministry of Science and ICT and the National Research Foundation of Korea Climate Change Response Technology Development business and was published in the latest volume of the international journal ‘Energy & Environmental Science’ (IF: 30.289, JCR field top 0.189%). (Left) Solid oxide fuel cell battery (Middle) Single atom catalyst formed on the cell interior surface (Right) Platinum atom dispersed on the catalyst surface (Bright spot: platinum atom) (Photo by: KIST) Global News Team global@hanyang.ac.kr Translation by: Park Gyeong-min

2020-09 22

[Academics]Professor Kim Sung Shin, Discovers the Neural Scientific Reason on Learning Exercise Technique

Hanayng University announced on the 11th that Professor Kim Sung Shin of Hanyang University's Department of Cognitive Sciences discovered the neural scientific process for learning a new exercise technique. The Department of Cognitive Sciences will be newly constructed on 2021, which focuses on studies that connect the decision making process of humans and Artificial Intelligence, also creating new technologies. Humans learn various exercise techniques from life to death. Every movement of our lives, such as walking, picking food with chopsticks, playing instruments, and driving, are done by first learning the exercise techniques. In fact, there had not been any specific discovery on what is happening in our brain as these exercise techniques are being learned. Professor Kim's team observed the changes in the brain by providing new exercise techniques to the learner and using the fMRI (Functional Magnetic Resonance Imaging). Through the experiment, the team focused on the role of the tadpole-shaped caudate nucleus, which is related to rewarding within the brain areas. According to the observation, it has been found that as the learning proceeds, the information related to the reward for doing exercise moves from the head part to the tail part of the caudate nucleus. Additionaly, it has also been found that the head part of the caudate nucleus interacts with the frontal lobe of the cerebrum (Decision, assumption area), while the tail part of the caudate nucleus interacts with the motor cortex of the cerebrum (exercise technique area), and that an individual's capacity for exercise depends on the strength of the interactions. The results of this research hold meaning in discovering that the caudate nucleus, which takes part in pleasure, reward, and motive, also holds major a part in learning and habituating new exercise techniques. Professor Kim mentioned that, "through this research, the people will deeply understand the movement disability caused by parkinsonian syndrome and also create new perspectives on providing treatment for it." He also added, "furthermore, this will become an inspiration in creating an effective AI system, as well as understanding and developing the nural-machine access system." The reaserch, which has been supported by the Institute for Basic Science, was published on the PNAS (Proceedings of the National Academy of Sciences of the United States of America) on September 8th. Choi Ye-ra, and Shin Yoon-ha Resercher of the Institue for Basic Science Center for Neurosicence Imaging Research participated as the co-first-author of the paper, with Professor Kim Sung Shin as the corresponding author. (left) The computer cursor trail that the participants have left: As the learning proceeds, the participants learn how to move the cursor so that it can reach the four corners better using the movement of fingers. (right) Learning curve of 30 participants during the seven experiments The image explains the information on reward moves from the head to the tail part as the learning proceeds from the beginning to the end. The image explains that each caudate nucleus interacts with the frontal lobe and the motor cortex of the cerebrum, and that the strength of the interaction decides the exercise capacity. Check the information on [[Hanyang Wiki]] hyu.wiki/운동기술습득뇌과학 Global News Team global@hanyang.ac.kr Translation by: Lee Won-young

2020-09 09

[Academics]Hanyang University 4th Industrial Revolution Research Center registers a patent for efficient dust purification of underground tunnels

Hanyang University's Fourth Industrial Revolution Research Center registered a patent for efficient dust purification of underground tunnels on August 31. Professor Cho Byung-wan in her class The Hanyang University Industry-University-Research Cooperation Foundation completed the registration of a patent (patent registration number 10-2144020) for underground spaces using quantum energy fields and waterfalls, natural ventilation methods of tunnels, and purification systems. This is the result of a study by Professor Cho Byung-wan, the director of the Fourth Industrial Revolution Research Institute and a professor in the Department of Civil and Environmental Engineering, to solve the fine dust problem in underground tunnel spaces, such as subways, which is one of the causes of fine dust in Korea. Along with the recent increase of subway construction, the number and length of tunnels has increased, causing air inside the tunnels to flow into the outlet without being ventilated properly with the outside and not purified, causing urban fine dust. The air inside such tunnels contain a number of pollutants that are harmful to the human body, such as micro dust, nitrogen oxides (NOx), sulfur oxides (Sox), formaldehyde, and volatile organic compounds (VOCs). In the case of subways, most of the operating sections are made of underground spaces, which by the piston effect causes train wind when the train enters or leaves the underground station. Such train winds are threatening the health of citizens as fine dust enters the platform through cracks in the screen as well as causing noise, resulting in major air pollution in the platform and on the train. To purify the air inside the tunnel, a jet-fan is installed inside the tunnel and filters are applied in ventilation facilities to filter pollutants. In general, expensive purification filters are rarely used due to huge operating costs and noise problems caused by huge electricity consumption of fan-type dust collectors. Fine dust collection vehicles and cleaning vehicles are operated as temporary measures if necessary, but the actual purification effect is insignificant. The patent describes the natural ventilation methods and devices that maximize the flow of the energy field-based Bernoulli fluid, which is identified by the new advanced quantum mechanics by applying advanced scientific technology in the era of the fourth industrial revolution. Furthermore, it also provides technologies for increasing the flow rate of polluted air inside the tunnel using the sectional change through the dust collector and natural ventilation methods and devices for underground space tunnels using plasma and waterfalls that purify the internal air in real time through quantum energy field-based nano plasma light falls or nano hydrogen antioxidant spray falls in the space of the tunnel. Professor Cho said, "We will consult as the world's first scientific system to solve the serious global fine dust problem in subways including developed countries, so that it can be extensively used in the construction of subways, roads and underwater tunnels around the world with the technology of the fourth industrial revolution, so that it can become a breakthrough in Korea’s construction and management of tunnels." Global News Team global@hanyang.ac.kr Translation by: Park Gyeong-min

2020-08 26

[Academics]Professor Sun Yang-guk's Joint Research Team Publishes a Paper Reviewing Lithium Oxygen Batteries

A joint research team led by Professor Sun Yang-guk, Department of Energy Engineering at Hanyang University, published a paper reviewing lithium oxygen batteries which is one of the next-generation secondary battery systems. The joint research team includes Professor Sun Yang-guk of Hanyang University, Professor Kwak Won-jin of Ajou University, Professor Doron Aurbach of Israel's Biran University, Professor Peter Bruce of Oxford University in the U.K., and Professor Linda Nazar of Waterloo University in Canada. The paper was titled "Lithium–Oxygen Batteries and Related Systems: Potential, Status, and Future" and was selected as a cover paper for theJuly 22 online edition of "Chemical Review." The research team introduced he structure, driving principles and related derived systems of lithium oxygen batteries based on their experiences and achievements. It also pointed out the key problems in relation to lithium oxygen batteries, latest research trends, and improvement directions considering practicality. Lithium oxygen cells are next-generation secondary battery systems that utilize oxygen in the air as an energy source. It also has the potential to surpass the theoretical enery density limts of lithium ion batteries used in mobile phones and electric vehicles allowing active research. However, there are limitations like low energy efficiency caused by irreversible generation and decomposition of short-term battery life products caused by negative reactions by oxygen. Therefore, innovative research is required to solve these problems professionally. Meanwhile, Professor Sun was recognized as one of the best 10 scientists in the field of lithium-ion batteries by Research Interfaces. The paper was selected as the best paper researcher of the school in 2020, and currently holds 599 SCI-level papers and 456 domestic and foreign patents. In particular, he was recognizedas the "world's most influential top 1% researcher" by Claribate Analytics. ▲ A part of the paper "Lithium–Oxygen Batteries and Related Systems: Potential, Status, and Future" More on Hanyangwiki hyu.wiki/선양국 Global News Team global@hanyang.ac.kr Translation by: Lee Hee-jin

2020-08 20

[Academics]Professor Chung Yun-suk’s Joint Research Team Develops Digital Twin Modeling Technology

Hanyang University's Department of Energy Engineering's Professor Chung Yun-suk’s research team and DGIST Professor Lee Yong-min's research team jointly succeeded in developing a high-reliability digital twin solid-state battery model. The Digital Twin is a technology that copies the exact same material in a virtual space. Through this technology, the research teams copied a sulfide system solid-state battery, which is difficult to deal with in a natural environment, in a virtual space. They have made possible copying a real battery in a virtual space to analyze physical phenomena that happen inside the battery and to predict changes in property according to diverse designs. Through this research outcome, the research teams provided a clue to advancing the commercialization of solid-state batteries and explained that they are expecting to spread as a platform for other electrodes and battery systems. This research was carried out with the support of the climate change response plan technology development business and the future materials discovery project promoted by the Ministry of Science & ICT and the National Research Foundation of Korea. The research results were published in an international journal in the field of energy materials, Advanced Energy Materials on July 26th. ▲Digital Twin solid-state electrode and the real solid-state electrode <photo by: DGIST> Global News Team global@hanyang.ac.kr Translation by: Park Gyeong-min

2020-08 20

[Academics]Joint Research Team of Professor Yoo Won-chul Developed High Energy Density Foldable Super Capacitor

The joint research team of Hanyang University's Professor Yoo Won-chul of the Department of Chemical and Molecular Engineering and Inha University's Professor Lee Keun-hyung of the Department of Chemical Engineering developed a solid supercapacitor that has high energy density. The supercapacitor is a reinforced form of capacitor, especially reinforcing the capacity of electricity among the capacities of a condenser. The electric charges are stored on the surface of porous electrodes, by absorption and desorption of electrolyte ions. This leads to having high power density and fast-changing and discharging speeds. However, the existing supercapacitor had limited applications of its use due to its low energy compared to batteries. It was mainly used as a power aid in electric vehicles. The joint research team drastically improved the energy storage characteristic of the supercapacitor by using porous carbon with three-dimensional connective structures, which was designed to facilitate the ion movement and ionic liquid-based polymeric electrolytes that have high electrochemical stability. The team also developed a foldable supercapacitor that can be adjusted to various sizes and shapes by applying polymeric electrolytes. The capacitor operates without any changes in performance even when fully folded, raising the possibility of being used as an energy storage device for wearable electronic devices that have been actively researched and developed. This research was conducted with the support of the National Research Foundation of Korea and was published on the cover of Advanced Functional Materials volume 30, issue 30, on July 23, 2020. Cover of Advanced Functional Materials Global News Team global@hanyang.ac.kr Translation by: Lee Won-young

2020-08 13

[Academics]Hanyang University 4th Industrial Revolution Research Center Published the "5th Industrial Revolution Prediction Report"

On the 10th, the Hanyang University 4th Industrial Revolution Research Center published the "Measures on Earth's Glacial Epoch and Pandemic During the 5th Industrial Revolution Era," which is a strategy report according to predictions about the 5th Industrial Revolution. The research report does not view the increase in greenhouse gases and carbon emissions as the only causes of global warming and other changes in the ecosystem. Instead, it considers the fundamental case from the view of the most recent theory of relativity and quantum mechanics. It predicts the danger of glacial epoch which can bring about the extinction of the ecosystem, while also specifically presenting applicable green and environmental energy policies which will replace some renewable energy businesses that are not largely economic. The report also deals with response strategies to the COVID-19 pandemic, a platform of methods to limit the spread of epidemics in cities, an economic rescue plan through the smart city, how to carry out K-epidemics using IoT, AI robots, and blockchain technology. Professor Cho Byung-wan of the Hanyang University 4th Industrial Revolution Research Center mentioned that "the report predicts and analyzes the upcoming 5th Industrial Revolution, starting from presenting energy strategies on COVID-19 and global warming to the world's first smart city construction methods." However, the report has a total of three volumes. The first volume is "Amazing 5th Industrial Revolution," the second volume is called "Glacial Epoch and Response to a Pandemic During the 5th Industrial Revolution," and the third volume is "Changes in the Religion/Salvation of Humans." Global News Team global@hanyang.ac.kr Translation by: Lee Won-young

2020-08 07

[Academics]Joint Research Team of Hanyang and Kyunghee University Redefined New Gene Cause of Rheumarthritis

6 New Gene Causes of Rheumarthritis (SLAMF6, CXCL13, SWAP70, NFKBIA, ZFP36L1, LINC00158), an autoimmune disease that destructs itself, has been found along with a new gene cause (SH2B3) that is found exclusively in East Asians. Professor Bae Sang-chul The joint research team led by Professor Bae Sang-chul of Hanyang University Hospital for Rheumatic Diseases Department of Rheumatism and Professor Kim Kwang-woo of Kyunghee University Department of Biology, participated in by the Center for Genome Science under the Korea National Institute of Health and other university hospitals in Korea, published the above facts in the Annals of Rheumatic Diseases on July 28th. The research was conducted through rigorous analysis of the genome genetic drift of both patients and non-patients of rheumatism in Korea, using the Korean Chip technology that has been developed by the Center for Genome Science under the Korea National Institue of Health. Furthermore, through computational biology based on genetic drift, transcriptome, and the epigenome, the research team also clarified that the genetic drift related to rheumatic diseases can also be part of the cause of the disease in the tissues of the lungs and small intestine. Rheumatoid arthritis is an autoimmune disease that is caused when the immune system abnormally attacks the body tissues. This causes inflammation and pain around the joints and the tissues around them, also leading to possible permanent disability or organ damage caused by joint deformation. Rheumarthritis is known to have a high prevalence rate and therefore leads to an economic burden for patients. The cause of rheumatoid arthritis is a combination of many genetic variants and environmental factors. Bae Sang-chul President of Hanyang University Hospital for Rheumatic Diseases mentioned that "due to this discovery we were able to understand the development mechanism of rheumatism," and added that "genetic variants like this can be used to predict and diagnose rheumatism, allowing for more specified and advanced treatment of the disease." Also, this research holds a bigger meaning since "it provided a clue to the existing studies of genetic characteristics regarding the effects of the mucous membrane of our lungs and small intestine on autoantibody production." The research was conducted through the support of Hanyang University Research Institute for Rheumatology Research, the National Research Foundation of Korea, the Ministry of Health and Welfare, and the National Institute of Health. The first authors of the research are Dr. Kwon Young-chang (Hanyang University Institute for Rheumatology Research), student Lim Ji-woo (Kyunghee University Departement of Biology), Professor Bang So-young (Hanyang University Guri Hospital), while Professor Bae Sang-chul and Kim Kwang-woo participated as joint corresponding authors. Global News Team global@hanyanc.ac.kr Translation by: Lee Won-young

2020-07 27 Important News

[Academics][Researcher of the Month] Customizing Breast Cancer Treatment through Big Data

In 2015, Professor Kong Gu (College of Medicine) was a pioneer in the field of breast cancer research and treatment, laying the foundation for web-based precision by mapping 560 breast cancer whole-genome sequences. Kong is now developing a screening system for breast cancer with multiomics and big data, paving the way for customization and personalized breast cancer treatment. Professor Kong Gu (College of Medicine) developed a target gene screening system for the diagnosis and treatment of breast cancer. Breast cancer is one of the most common types of cancer among women, causing death to 1 out of 38 women. The cancer is classified into three subtypes, which are Estrogen Receptor (ER) positive, HER2 positive, and triple-negative. The latter two – which make up fewer than 30 percent of all cases – usually have bad prognoses. Through this research project, Kong sought to find the target gene of malignant tumors through multiomics. Multiomics is a new approach where the data sets of different omic groups, such as the genome, proteome, and transcriptome, are combined during analysis. By unpacking 41 data sets from METABRIC, TCGA, and GEO, Kong made a target gene screening system that allows researchers to customize the treatment of potential patients. “It is a platform to provide the individualized surgical target with data visualization,” explained the professor. Data visualization, survival analysis, and target gene screening are three main points in this research. (Photo courtesy of Kong) Kong, who is one of the first Korean scholars to introduce the polymerase chain reaction (PCR) test, said it was a challenge for him to conduct this research. “Most of what I have studied as a researcher was on biotechnology(BT),” said Kong. The latest research, however, involved informational technology (IT). He said a lot of help was given to him from Kim Hyung Yong, a Ph.D. candidate who majored in bioinformatics for his master’s degree. Kong tried to learn IT himself, as well as to pass his knowledge of breast cancer on to his doctoral student. “It was an opportunity to remind me that the path of learning is long and winding," recalled Kong. Kong said it was definitely a challenge to encounter informational technology (IT) in his research. Kong advised the members of Hanyang to be engrossed in their path. “Stay focused on your interests with constant effort,” advised the professor. “You will eventually become an expert in the field.” Oh Kyu-jin alex684@hanyang.ac.kr

2020-07 26 Important News

[Academics][Excellent R&D] How to Ensure Structural Safety During Remodeling

Professor Choi Chang-sik (Department of Architectural Engineering) has developed the technology to ensure structural safety when vertically extending buildings. Unlike previous methods, Choi's method strengthens the existing wall structure without adding to or thickening of the walls; thus, it does not reduce the floor space. Out of all residential premises in South Korea, 55 percent are more than 30 years old (figure from 2018). When a building is decrepit, it can either be demolished and reconstructed or partly remodeled. Choi's research aims to deal with problems that arise while remodeling, especially when doing a vertical extension. Professor Choi-Chang-sik (Department of Architectural Engineering) is explaining the reason why shear walls are important when extending a building. To increase the number of floors of a building, many aspects must be considered. These include the vertical weight that will be put on the walls and pillars, horizontal weight which is related to wind and earthquakes, as well as the flexural strength. The taller the building, the more stress is put on the importance of the horizontal weight and flexural strength. The type of wall that is designed to support these two factors is called a shear wall. Choi's method of strengthening sheer walls differs from the previous adhesion-type method in that it does not thicken the walls or increase the number of walls. He first calculates the necessary thickness of the stiffener and cuts out the same size area from the existing wall structure. The stiffener is then applied onto the vacant area. This method gives the advantage that it will not reduce the actual floor space of the living area. Choi explained that the team has successfully finished the technology development as well as completed testing on real-scale structures. The only thing left is to test it on an actual building. "We are currently facing difficulties because there are not many complexes that are willing to try out the new technology. Furthermore, apartments in general do not prefer remodeling over reconstruction, so it is very hard to find an apartment to apply our method on," said Choi. “People feel vague anxiety about reusing an old structure as the base. However, remodeling involves as much technical verification as reconstruction. I hope people can trust the safety of our remodeling method." Hwang Hee-won whitewon99@hanyang.ac.kr