[Medical Daily] Improving Weight Loss by Exploiting Genetic Code
Professor Kim Yong-hee (Department of Bio-engineering) performs a study to avoid side effects of anti-obesity drugs
|Copy URL / Share SNS||
There are many existing ways developed to overcome obesity and losing lots of weight. Prescription weight loss medications are increasingly popular, aside from the traditional way of going on a diet and exercising.
A Hanyang University research team led by professor Kim Yong-hee (Department of Bio-engineering) looked into ways to improve weight loss by exploiting our genetic code, and to avoid the side effects of anti-obesity drugs. The research team used “CRISPR interference (CRISPRi),” which is a modified CRISPR gene editing tool for the study. The CRISPRi does not alter the genetic code permanently but simply interferes with gene expression, allowing either activation or repression of gene expression. It regulates the genome instead of modifying it.
By applying CRISPRi technology, Kim and the research team could reduce the fabp4 expression level by up to 60 percent. Obese and diabetic mice were injected peptide-targeting CRISPRi twice a week for as long as six weeks, and the result turned out that the tested mice lost around 20 percent of body weight. Consumed food was not different from normal, which indicated that the weight loss did not occur due to eating less.
The study is meaningful in that it approaches obesity in a different perspective compared to the traditional pharmaceutical approach.
The research team concluded that they still need to work on the clinical application of injecting peptide-targeting CRISPRi in a human model. Whether the regimen can be applied twice a week for up to 6 weeks is still uncertain.
Read Full Article: https://www.medicaldaily.com/gene-editing-answer-obesity-441832
This week's top news
Korean Couple Culture
Korean Traditional Colors
2017 JoongAng Ilbo University Rankings, Seoul Ranked 3rd · ERICA 9th
Kimchi, Korea’s Historical and Conventional Icon
Contrast between Korean and English
Professor Kim Yoo-jeong, Awarded the 'Travel Grant' from the Association for Research in Vision and Ophthalmology
Hanyang Made Remarkable Achievements in This Year's National Examinations Results
Hanyang University ranked 25th in the QS Asian University Rankings and claimed 5th in the domestic universities
National & World University Rankings in 2017
[Full Text] A Congratulatory Speech from the President of Hanyang University During the 81st Anniversary Ceremony